Improving the reliability and ecological validity of pharmaceutical risk assessment: Turquoise killifish ( Nothobranchius furzeri ) as a model in behavioral ecotoxicology
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چکیده
منابع مشابه
Transposon-Mediated Transgenesis in the Short-Lived African Killifish Nothobranchius furzeri, a Vertebrate Model for Aging
The African killifish Nothobranchius furzeri is the shortest-lived vertebrate that can be bred in captivity. N. furzeri comprises several wild-derived strains with striking differences in longevity ranging from 3 to 9 months, which makes it a powerful vertebrate model for aging research. The short life cycle of N. furzeri should also facilitate studies on adult traits that are specific to verte...
متن کاملA microinjection protocol for the generation of transgenic killifish (Species: Nothobranchius furzeri).
BACKGROUND A challenge in age research is the absence of short-lived vertebrate model organisms. The turquoise killifish Nothobranchius furzeri has an exceptionally short lifespan of 4-10 months depending on the strain. Thus, it possesses the shortest known maximum lifespan of a vertebrate species that can be bred in captivity. RESULTS Here we show the successful introduction of DNA and RNA m...
متن کاملNothobranchius furzeri: A Model for Aging Research and More.
The short-lived killifish Nothobranchius furzeri inhabits ephemeral ponds in southeastern Africa and is characterized by rapid growth and early sexual maturation. With respect to the molecular, cellular, and integrative traits of aging, N. furzeri shows significant similarities to mammals, including humans. Recently, reference sequences for the N. furzeri genome have been published. Also, metho...
متن کاملTurquoise killifish
Reichard et al. introduce the turquoise killifish (Nothobranchius furzeri), notable for its short-life span and diapause stage.
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ژورنال
عنوان ژورنال: Environmental Toxicology and Chemistry
سال: 2018
ISSN: 0730-7268,1552-8618
DOI: 10.1002/etc.4301